Across TCGA pan-cancer cohorts, MIR3157 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR3157’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where MIR3157 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR3157 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
ESCA are the cancer types where MIR3157 tumor–normal differential expression is most reproducible.