Across TCGA pan-cancer cohorts, MIR3140 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR3140’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR3140 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR3140 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC, BRCA, and THCA are the cancer types where MIR3140 tumor–normal differential expression is most reproducible.