Across TCGA pan-cancer cohorts, MIR30C2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MIR30C2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR30C2 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR30C2 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.
KIRC, BLCA, and THCA are the cancer types where MIR30C2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR30C2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.