Across TCGA pan-cancer cohorts, MIR30C1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR30C1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR30C1 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR30C1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC and KIRP are the cancer types where MIR30C1 tumor–normal differential expression is most reproducible.