Across TCGA pan-cancer cohorts, MIR30A RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR30A’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIR30A RNA is repressed in tumor relative to normal tissue. In most cancer types MIR30A is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
KIRC are the cancer types where MIR30A tumor–normal differential expression is most reproducible.