Across TCGA pan-cancer cohorts, MIR2681 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR2681’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MIR2681 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR2681 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
STAD are the cancer types where MIR2681 tumor–normal differential expression is most reproducible.