MIR222HG

Across TCGA pan-cancer cohorts, MIR222HG RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MIR222HG’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MIR222HG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR222HG is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

THCA, KIRC, and BRCA are the cancer types where MIR222HG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR222HG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	+2.421	<.001	11	view →
KIRC	All	II,III,IV	−0.386	.001	8	view →
BRCA	All	III,IV	−1.422	<.001	6	view →
BLCA	All	All	−1.137	.008	6	view →
UCEC	All	All	−1.075	<.001	6	view →
COAD	All	All	+0.647	<.001	6	view →
STAD	All	II,III,IV	+0.773	.004	5	view →
KIRP	All	II,III,IV	−0.686	.009	4	view →
LIHC	All	II,III,IV	+0.380	.003	4	view →
CHOL	All	All	+1.447	<.001	3	view →
KICH	All	All	+0.856	.003	3	view →
LUSC	All	All	−0.622	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MIR222HG–THCA

Open the THCA breakdown →