Across TCGA patient cohorts, MIR221 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIR221-associated genes across cancer lineages are RNU6-1123P, NDUFS6P1, and RN7SKP132. Each is linked with MIR221 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR221-to-partner and partner-to-MIR221 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR221→partner) and Y-score (partner→MIR221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1123P →	+0.706	+5.551	<.001	.004	3	1
UCEC	NDUFS6P1 →	+0.388	+5.242	<.001	.007	3	1
UCEC	RN7SKP132 →	+0.363	+6.877	<.001	<.001	3	1
UCEC	RNU6ATAC17P →	+0.907	+5.186	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

MIR221 survival (RNA) · tumor vs normal (RNA) · all MIR221 data types