Across TCGA pan-cancer cohorts, MIR199A2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR199A2’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where MIR199A2 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR199A2 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.
UCEC, KICH, and KIRP are the cancer types where MIR199A2 tumor–normal differential expression is most reproducible.