Across TCGA pan-cancer cohorts, MIR187 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIR187’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MIR187 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR187 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.
KIRP, KIRC, and KICH are the cancer types where MIR187 tumor–normal differential expression is most reproducible.