Across TCGA pan-cancer cohorts, MIR181C RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR181C’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR181C RNA is repressed in tumor relative to normal tissue. In most cancer types MIR181C is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, THCA, and KIRP are the cancer types where MIR181C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR181C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.134	.003	4	view →
THCA	All	All	+0.136	.018	3	view →
KIRP	All	III,IV	+0.152	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MIR181C RNA expression & survival · all MIR181C data types