Across TCGA pan-cancer cohorts, MIR150 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR150’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR150 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR150 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.
LUSC, KICH, and LIHC are the cancer types where MIR150 tumor–normal differential expression is most reproducible.