Across TCGA pan-cancer cohorts, MIR149 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MIR149 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher MIR149 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR149 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

LIHC, OV, and THCA are the cancer types where MIR149 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.176	0.719	<.001	108	view →
OV	OS	Median	II,III,IV	0.250	0.401	<.001	96	view →
THCA	OS	Tertile	III,IV	0.684	0.909	<.001	78	view →
BLCA	OS	Median	All	0.682	0.551	.001	46	view →
KIRC	DFS	Tertile	All	0.433	0.667	.004	45	view →
UVM	DFS	Tertile	II,III,IV	0.339	0.626	.009	42	view →
ACC	DFS	Tertile	All	0.193	0.659	.004	36	view →
KICH	DFS	Tertile	III,IV	0.025	0.773	<.001	36	view →
MESO	OS	Quartile	All	0.143	0.635	<.001	33	view →
CESC	DFS	Tertile	II,III,IV	0.557	0.780	.007	30	view →
BRCA	OS	Tertile	III,IV	0.924	0.787	.009	25	view →
LUSC	DFS	Tertile	II,III,IV	0.572	0.744	.007	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

Exploration

Same gene, other analysis: MIR149 tumor-vs-normal RNA expression · all MIR149 data types