Across TCGA pan-cancer cohorts, MIR148B RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MIR148B’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR148B RNA is repressed in tumor relative to normal tissue. In most cancer types MIR148B is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.
LUSC, BLCA, and BLCA are the cancer types where MIR148B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR148B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.