Q-omics provides the consensus-scored MIR146B profile across patient tissues and cancer cell-line models. MIR146B expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MIR146B is differentially expressed in 8, with the highest sampling consensus in THCA. Additionally, MIR146B RNA expression shows 13,416 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, THCA, and LSCC as cancer lineages where MIR146B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR146B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR146B survival associations across molecular data types. MIR146B RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR146B RNA expression–survival associations across cancer types. High MIR146B expression shows unfavorable associations in ACC, KIRC, UVM, CHOL, DLBC and BLCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for MIR146B RNA expression.
This table summarizes MIR146B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MIR146B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR146B shows lower tumor expression in LUSC and KICH and higher tumor expression in THCA, KIRC, COAD and LUAD. The THCA box plot shows higher MIR146B RNA expression in tumor versus normal tissue (log2 FC = +3.187, t-test p < 0.001).
This table shows molecular features associated with MIR146B in patient tissues and cancer cell lines. In patient samples, MIR146B shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
