Across TCGA pan-cancer cohorts, MIR135B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MIR135B’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where MIR135B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR135B is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
COAD, HNSC, and LUAD are the cancer types where MIR135B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR135B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.