Across TCGA pan-cancer cohorts, MIR130A RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR130A’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR130A RNA is repressed in tumor relative to normal tissue. In most cancer types MIR130A is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where MIR130A tumor–normal differential expression is most reproducible.