Across TCGA pan-cancer cohorts, MIR1302-5 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR1302-5’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MIR1302-5 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR1302-5 is over-expressed in tumor, although a few such as KIRP and LUSC show the opposite, repressed pattern.
KIRP and LUSC are the cancer types where MIR1302-5 tumor–normal differential expression is most reproducible.