Across TCGA pan-cancer cohorts, MIR1295A RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR1295A’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR1295A RNA is repressed in tumor relative to normal tissue. In most cancer types MIR1295A is over-expressed in tumor, although a few such as BRCA and CHOL show the opposite, repressed pattern.
BRCA, CHOL, and LIHC are the cancer types where MIR1295A tumor–normal differential expression is most reproducible.