Across TCGA pan-cancer cohorts, MIR1289-1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MIR1289-1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MIR1289-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MIR1289-1 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

UCS, KIRC, and CHOL are the cancer types where MIR1289-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.700	0.280	.005	80	view →
KIRC	OS	Tertile	All	0.473	0.678	<.001	76	view →
CHOL	OS	Tertile	II,III,IV	0.089	0.712	.001	72	view →
THCA	OS	Tertile	All	0.562	0.966	<.001	57	view →
KICH	DFS	Tertile	II,III,IV	0.440	0.886	.002	54	view →
MESO	DFS	Tertile	II,III,IV	0.244	0.417	.006	54	view →
COAD	OS	Tertile	III,IV	0.541	0.819	.003	45	view →
BLCA	DFS	Tertile	III,IV	0.284	0.539	.001	42	view →
LAML	DFS	Median	All	0.441	0.707	.003	26	view →
BRCA	DFS	Tertile	IV	0.789	0.418	.030	21	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	18	view →
PAAD	OS	Tertile	II,III,IV	0.295	0.569	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: MIR1289-1 tumor-vs-normal RNA expression · all MIR1289-1 data types