MIR1270

Across TCGA patient cohorts, MIR1270 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIR1270-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1173, and PCNA. Each is linked with MIR1270 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIR1270-to-partner and partner-to-MIR1270 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MIR1270-low versus MIR1270-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIR1270→partner) and Y-score (partner→MIR1270) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.710	+3.807	<.001	<.001	3	2
UCEC	EGFR_pY1173 →	+0.076	+2.341	.011	.019	3	2
UCEC	PCNA →	+0.312	+2.906	<.001	.001	3	2
UCEC	PDCD4 →	-0.489	-1.415	.005	.046	3	2
UCEC	Smad3 →	+0.138	+2.115	.014	.017	3	2
UCEC	STAT3_pY705 →	-0.395	-1.765	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-B1 by MIR1270 expression — UCEC

Explore this box plot interactively →