Across TCGA pan-cancer cohorts, MIR1269B RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of MIR1269B’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MIR1269B RNA is repressed in tumor relative to normal tissue. In most cancer types MIR1269B is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC are the cancer types where MIR1269B tumor–normal differential expression is most reproducible.