Across TCGA pan-cancer cohorts, MIR1268B RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MIR1268B’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where MIR1268B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR1268B is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
LUAD, THCA, and LIHC are the cancer types where MIR1268B tumor–normal differential expression is most reproducible.