Across TCGA pan-cancer cohorts, MIR125B2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR125B2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR125B2 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR125B2 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and STAD are the cancer types where MIR125B2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR125B2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.492	<.001	6	view →
KICH	All	All	−0.395	.005	4	view →
STAD	All	All	−0.463	.021	2	view →
KIRP	Male	All	−0.350	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MIR125B2 RNA expression & survival · all MIR125B2 data types