MIR124-2HG

Across TCGA pan-cancer cohorts, MIR124-2HG RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated MIR124-2HG data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MIR124-2HG RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MIR124-2HG expression acts as an unfavorable survival marker, although some lineages such as LUSC and LGG show a favorable association.

KIRP, LUSC, and COAD are the cancer types where MIR124-2HG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.299	0.713	<.001	108	view →
LUSC	OS	Tertile	All	0.880	0.738	.002	66	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	45	view →
LGG	DFS	Quartile	All	0.561	0.353	<.001	39	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	19	view →
BRCA	DFS	Tertile	III,IV	0.695	0.886	.006	18	view →
KIRC	DFS	Tertile	IV	0.223	0.532	.031	12	view →
PCPG	OS	Tertile	All	0.763	1.000	.003	12	view →
LIHC	OS	Tertile	II,III,IV	0.231	0.620	.047	9	view →
UCEC	OS	Tertile	All	0.515	0.694	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

MIR124-2HG–KIRP (OS)

Open the KIRP breakdown →