Across TCGA pan-cancer cohorts, MIR1200 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR1200’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where MIR1200 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR1200 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.
THCA and LUSC are the cancer types where MIR1200 tumor–normal differential expression is most reproducible.