Across TCGA pan-cancer cohorts, MIR1180 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MIR1180’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where MIR1180 RNA is repressed in tumor relative to normal tissue. In most cancer types MIR1180 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.
BRCA, PAAD, and UCEC are the cancer types where MIR1180 tumor–normal differential expression is most reproducible.