MIPOL1

Across TCGA patient cohorts, MIPOL1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIPOL1-associated genes across cancer lineages are JNK2, Notch1, and TFRC. Each is linked with MIPOL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIPOL1-to-partner and partner-to-MIPOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by MIPOL1-low versus MIPOL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIPOL1→partner) and Y-score (partner→MIPOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.205	+2.424	.002	.001	3	2
UCEC	Notch1 →	+0.119	+2.013	.015	.016	3	2
UCEC	TFRC →	+0.552	+3.000	.002	<.001	3	2
UCEC	TIGAR →	+0.117	+1.584	.026	.034	3	2
UCEC	14-3-3_beta →	-0.101	-2.880	.003	.001	3	1
UCEC	EGFR_pY1068 →	-0.237	-2.115	.006	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

JNK2 by MIPOL1 expression — UCEC

Explore this box plot interactively →