MIPOL1

Across TCGA cell cohorts, MIPOL1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIPOL1-associated genes across cancer lineages are DEFB124, DPEP2NB, and OR6B1. Each is linked with MIPOL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIPOL1-to-partner and partner-to-MIPOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by MIPOL1-low versus MIPOL1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIPOL1→partner) and Y-score (partner→MIPOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DEFB124 →	+0.108	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	DPEP2NB →	+0.038	+4.067	<.001	.001	3	1
STOMACH	OR6B1 →	+0.015	+4.285	<.001	.007	3	1
STOMACH	RD3L →	+0.045	+4.129	<.001	.007	3	1
LARGE_INTESTINE	TCL1B →	+0.591	+3.201	<.001	.007	3	1
LARGE_INTESTINE	LACTBL1 →	+0.029	+3.217	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DEFB124 by MIPOL1 expression — BLOOD_Lymphoma

Explore this box plot interactively →