MIPEP

Across TCGA patient cohorts, MIPEP mutation is significantly associated with the RNA expression of many other genes, with 3,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIPEP-associated genes across cancer lineages are HAUS8, FEN1, and WDHD1. Each is linked with MIPEP in more than 2 cancer types. Because this analysis shows association rather than direction, both MIPEP-to-partner and partner-to-MIPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS8 grouped by MIPEP-low versus MIPEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIPEP→partner) and Y-score (partner→MIPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HAUS8 →	+0.473	+2.263	<.001	<.001	3	3
UCEC	FEN1 →	+0.700	+4.010	<.001	<.001	3	3
UCEC	WDHD1 →	+0.705	+2.284	<.001	<.001	3	3
COAD	TUBB1P2 →	+0.015	+5.741	<.001	<.001	3	3
UCEC	CHAF1A →	+0.762	+3.136	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.762	+2.295	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,268 associations by consensus.

HAUS8 by MIPEP expression — UCEC

Explore this box plot interactively →