MIPEP

Across TCGA patient cohorts, MIPEP mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIPEP-associated genes across cancer lineages are C-Raf, MEK1, and Notch1. Each is linked with MIPEP in more than 2 cancer types. Because this analysis shows association rather than direction, both MIPEP-to-partner and partner-to-MIPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MIPEP-low versus MIPEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIPEP→partner) and Y-score (partner→MIPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.182	+2.222	<.001	.010	3	3
UCEC	MEK1 →	+0.412	+2.392	.001	<.001	3	2
UCEC	Notch1 →	+0.142	+1.362	.004	.037	3	2
UCEC	STAT3_pY705 →	-0.434	-2.492	<.001	.001	3	2
UCEC	ASNS →	+0.407	+2.222	.001	.010	3	2
UCEC	Bax →	+0.225	+2.222	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

C-Raf by MIPEP expression — UCEC

Explore this box plot interactively →