MIP

Across TCGA cell cohorts, MIP mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIP-associated genes across cancer lineages are KRTAP12-1 and LRRTM3. Each is linked with MIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MIP-to-partner and partner-to-MIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP12-1 grouped by MIP-low versus MIP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIP→partner) and Y-score (partner→MIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP12-1 →	+0.085	+5.569	<.001	.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.004	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

KRTAP12-1 by MIP expression — BLOOD_Leukemia

Explore this box plot interactively →