MIOS

Across TCGA pan-cancer cohorts, MIOS mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MIOS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MIOS mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MIOS is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where MIOS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIOS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.320	<.001	11	view →
CCRCC	All	All	−0.064	.001	9	view →
HNSC	Male	All	−0.211	<.001	8	view →
LSCC	All	III,IV	−0.146	<.001	8	view →
PDAC	Female	All	−0.285	<.001	7	view →
LUAD	All	All	+0.090	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MIOS–COAD

Open the COAD breakdown →