MIOS

Across TCGA patient cohorts, MIOS RNA expression is significantly associated with the protein abundance of many other proteins, with 12,247 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MIOS-associated proteins across cancer lineages are BRAT1, C7orf50, and FOXK1_S101. Each is linked with MIOS in more than 5 cancer types. Because this analysis shows association rather than direction, both MIOS-to-partner and partner-to-MIOS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MIOS versus BRAT1 in LSCC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOS→partner) and Y-score (partner→MIOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BRAT1 →	+0.317	+0.396	<.001	<.001	3	6
OV	C7orf50 →	+0.515	+0.575	<.001	<.001	3	6
PDAC	FOXK1_S101 →	+0.570	+0.226	.004	.003	3	5
BRCA	GGCT →	+0.396	+0.352	<.001	<.001	3	5
OV	ANKMY2 →	+0.321	+0.488	<.001	<.001	3	5
GBM	MLH1 →	+0.303	+0.329	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,247 associations by consensus.

MIOS vs BRAT1 — LSCC

Explore this scatter interactively →