MIOS

Across TCGA patient cohorts, MIOS mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIOS-associated genes across cancer lineages are INPP4B, PCNA, and Caspase-7-cleavedD198. Each is linked with MIOS in more than 2 cancer types. Because this analysis shows association rather than direction, both MIOS-to-partner and partner-to-MIOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by MIOS-low versus MIOS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOS→partner) and Y-score (partner→MIOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.275	-1.906	.012	.015	3	2
UCEC	PCNA →	+0.181	+1.514	.013	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.614	+2.242	.002	.005	3	2
UCEC	4E-BP1 →	+0.225	+3.321	.015	.009	3	2
UCEC	C-Raf →	+0.138	+1.807	.004	.004	3	2
BLCA	FoxM1 →	+0.251	+3.000	.040	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

INPP4B by MIOS expression — UCEC

Explore this box plot interactively →