MIOS

Across TCGA cell cohorts, MIOS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,013 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MIOS-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Regulation of isotype switching to IgG isotypes, and Meiotic mismatch repair. Each is linked with MIOS in more than 15 cancer types. Because this analysis shows association rather than direction, both MIOS-to-partner and partner-to-MIOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by MIOS-low versus MIOS-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOS→partner) and Y-score (partner→MIOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of isotype switching to IgG isotypes →	+0.141	+0.988	<.001	.002	3	16
PANCREAS	Regulation of isotype switching to IgG isotypes →	+0.133	+0.734	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Meiotic mismatch repair →	+0.119	+0.920	.002	<.001	3	14
BLOOD_Lymphoma	Subtelomeric heterochromatin formation →	+0.089	+0.827	<.001	<.001	3	12
BLOOD_Lymphoma	Regulation of DNA recombination →	+0.068	+1.142	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.064	+0.569	<.001	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,013 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by MIOS expression — BLOOD_Lymphoma

Explore this box plot interactively →