MIOS

Across TCGA cell cohorts, MIOS mutation is significantly associated with the mutation status of many other genes, with 2,630 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIOS-associated genes across cancer lineages are AP2A1, ADAMTS17, and DCAF1. Each is linked with MIOS in more than 3 cancer types. Because this analysis shows association rather than direction, both MIOS-to-partner and partner-to-MIOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP2A1 grouped by MIOS-low versus MIOS-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIOS→partner) and Y-score (partner→MIOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AP2A1 →	+2.870	+3.347	.009	.009	1	4
LARGE_INTESTINE	ADAMTS17 →	+1.691	+2.479	.008	.008	1	4
BLOOD_Lymphoma	DCAF1 →	+3.232	+3.523	.006	.006	1	4
SKIN	SGO2 →	+4.392	+4.392	.009	.009	1	4
BLOOD_Leukemia	PCDHB14 →	+3.115	+4.080	.001	.001	1	4
BLOOD_Lymphoma	EP300 →	+2.162	+3.187	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,630 associations by consensus.

AP2A1 by MIOS expression — BLOOD_Leukemia

Explore this box plot interactively →