MINPP1

Across TCGA patient cohorts, MINPP1 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MINPP1-associated genes across cancer lineages are METTL7AP1, TAS2R9, and OR1L4. Each is linked with MINPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MINPP1-to-partner and partner-to-MINPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL7AP1 grouped by MINPP1-low versus MINPP1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINPP1→partner) and Y-score (partner→MINPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	METTL7AP1 →	+0.097	+5.655	<.001	.004	3	2
HNSC	TAS2R9 →	+0.094	+5.241	<.001	.007	3	1
HNSC	OR1L4 →	+0.053	+5.822	<.001	.003	3	1
HNSC	DRD5P2 →	+0.021	+5.578	<.001	.004	3	1
HNSC	VN1R3 →	+0.078	+5.303	<.001	.006	3	1
HNSC	MIR302D →	+0.875	+5.069	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

METTL7AP1 by MINPP1 expression — HNSC

Explore this box plot interactively →