MINPP1

Across TCGA patient cohorts, MINPP1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MINPP1-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and Rab25. Each is linked with MINPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MINPP1-to-partner and partner-to-MINPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MINPP1-low versus MINPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINPP1→partner) and Y-score (partner→MINPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.231	+3.000	.004	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.754	+2.827	.028	.035	3	1
UCEC	Rab25 →	-0.593	-3.000	.001	.037	2	1
UCEC	C-Raf →	+0.247	+3.000	.002	.037	2	1
UCEC	EGFR_pY1068 →	-0.326	-3.000	.024	.037	1	1
UCEC	Myosin-IIa_pS1943 →	+0.357	+3.013	.002	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by MINPP1 expression — UCEC

Explore this box plot interactively →