MINDY4

Across TCGA pan-cancer cohorts, MINDY4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MINDY4 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher MINDY4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MINDY4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SARC, ESCA, and UCEC are the cancer types where MINDY4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.129	0.615	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.120	0.526	<.001	12	view →
UCEC	DFS	Median	All	0.969	0.828	.023	8	view →
PRAD	DFS	Median	All	0.615	0.936	.002	6	view →
SKCM	OS	Median	III,IV	0.569	0.841	<.001	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MINDY4–SARC (DFS)

Open the SARC breakdown →