MINDY4

Across TCGA pan-cancer cohorts, MINDY4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MINDY4 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MINDY4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MINDY4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where MINDY4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.492	0.945	.002	28	view →
PDAC	OS	Quartile	II,III,IV	0.675	0.264	.004	12	view →
LSCC	DFS	Quartile	All	0.909	0.643	.018	3	view →
LUAD	OS	Quartile	II,III,IV	0.890	0.439	.036	2	view →
GBM	OS	Median	All	0.658	0.867	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MINDY4–HNSC (OS)

Open the HNSC breakdown →