MINDY4

Across TCGA patient cohorts, MINDY4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MINDY4-associated genes across cancer lineages are mTOR_pS2448, Ku80, and PCNA. Each is linked with MINDY4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MINDY4-to-partner and partner-to-MINDY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MINDY4-low versus MINDY4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINDY4→partner) and Y-score (partner→MINDY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.137	-2.302	.012	.005	3	4
UCEC	Ku80 →	+0.222	+1.515	.010	.018	3	2
UCEC	PCNA →	+0.325	+3.392	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.598	+2.135	.006	.010	3	2
UCEC	Cyclin-B1 →	+0.679	+2.247	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.245	-2.247	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

mTOR_pS2448 by MINDY4 expression — UCEC

Explore this box plot interactively →