MINDY4

Across TCGA cell cohorts, MINDY4 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MINDY4-associated genes across cancer lineages are NPVF, KRTAP19-1, and GLYATL3. Each is linked with MINDY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MINDY4-to-partner and partner-to-MINDY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by MINDY4-low versus MINDY4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINDY4→partner) and Y-score (partner→MINDY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	KRTAP19-1 →	+0.033	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
OESOPHAGUS	SLC10A2 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	ZNF99 →	+0.023	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

NPVF by MINDY4 expression — KIDNEY

Explore this box plot interactively →