MINDY2

Across TCGA patient cohorts, MINDY2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MINDY2-associated genes across cancer lineages are STAT3_pY705, TFRC, and Cyclin-B1. Each is linked with MINDY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MINDY2-to-partner and partner-to-MINDY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by MINDY2-low versus MINDY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINDY2→partner) and Y-score (partner→MINDY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.380	-2.906	<.001	.001	3	2
UCEC	TFRC →	+0.484	+2.459	.031	.019	3	2
UCEC	Cyclin-B1 →	+0.632	+3.459	.007	.005	3	2
UCEC	FOXO3a_pS318_S321 →	-0.107	-1.990	.043	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-2.209	.027	.011	3	1
UCEC	Ku80 →	+0.288	+2.235	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

STAT3_pY705 by MINDY2 expression — UCEC

Explore this box plot interactively →