MINDY1

Across TCGA patient cohorts, MINDY1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MINDY1-associated genes across cancer lineages are Notch1, p62 Lck ligand, and Src. Each is linked with MINDY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MINDY1-to-partner and partner-to-MINDY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MINDY1-low versus MINDY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MINDY1→partner) and Y-score (partner→MINDY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.194	+2.817	.012	.036	3	2
UCEC	p62 Lck ligand →	+0.593	+2.999	<.001	.035	3	1
UCEC	Src →	+0.282	+3.169	.012	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+1.315	+3.169	<.001	.020	1	2
UCEC	Di-Ras3 →	-0.163	-3.169	.046	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by MINDY1 expression — UCEC

Explore this box plot interactively →