MILR1

Across TCGA patient cohorts, MILR1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MILR1-associated genes across cancer lineages are RNA5SP518, SNORD115-6, and RNU6-192P. Each is linked with MILR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MILR1-to-partner and partner-to-MILR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP518 grouped by MILR1-low versus MILR1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MILR1→partner) and Y-score (partner→MILR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP518 →	+0.358	+7.924	<.001	.008	3	2
BRCA	SNORD115-6 →	+0.418	+7.731	<.001	.009	3	1
SKCM	RNU6-192P →	+0.460	+7.219	<.001	<.001	3	1
SKCM	RNU6-172P →	+0.847	+5.037	<.001	.009	3	1
SKCM	CEACAMP2 →	+0.176	+5.362	<.001	.005	3	1
UCEC	RN7SL147P →	+0.304	+3.813	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

RNA5SP518 by MILR1 expression — LUSC

Explore this box plot interactively →