MIIP

Across TCGA patient cohorts, MIIP mutation is significantly associated with the RNA expression of many other genes, with 1,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIIP-associated genes across cancer lineages are DPH3, EXOG, and ZC3H18. Each is linked with MIIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MIIP-to-partner and partner-to-MIIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPH3 grouped by MIIP-low versus MIIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIIP→partner) and Y-score (partner→MIIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPH3 →	+0.598	+3.470	.001	.003	3	2
UCEC	EXOG →	+0.656	+3.332	<.001	.005	3	2
UCEC	ZC3H18 →	+0.600	+3.491	<.001	.002	3	2
UCEC	ARF4 →	+0.626	+3.480	.009	.002	3	2
UCEC	PDCD6IP →	+0.549	+3.459	.006	.005	3	2
UCEC	CDC7 →	+1.143	+3.330	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,198 associations by consensus.

DPH3 by MIIP expression — UCEC

Explore this box plot interactively →