MIIP

Across TCGA patient cohorts, MIIP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MIIP-associated genes across cancer lineages are LKB1, S6_pS235_S236, and SETD2. Each is linked with MIIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MIIP-to-partner and partner-to-MIIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by MIIP-low versus MIIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIIP→partner) and Y-score (partner→MIIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LKB1 →	+0.186	+3.037	.005	.017	3	2
SKCM	S6_pS235_S236 →	-0.604	-3.000	.012	.036	3	1
SKCM	SETD2 →	+0.174	+3.000	.034	.036	3	1
SKCM	4E-BP1_pT37_T46 →	-0.744	-3.000	.001	.035	3	1
SKCM	CD49b →	+0.403	+3.017	.002	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.276	+2.820	.029	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

LKB1 by MIIP expression — SKCM

Explore this box plot interactively →