MIIP

Across TCGA cell cohorts, MIIP mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIIP-associated genes across cancer lineages are THEG, MTNR1A, and NPAP1. Each is linked with MIIP in more than 1 cancer types. Because this analysis shows association rather than direction, both MIIP-to-partner and partner-to-MIIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THEG grouped by MIIP-low versus MIIP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIIP→partner) and Y-score (partner→MIIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	THEG →	+0.163	+3.091	<.001	.006	3	1
BLOOD_Leukemia	MTNR1A →	+0.087	+3.239	<.001	.004	3	1
BLOOD_Leukemia	NPAP1 →	+0.066	+3.381	<.001	.002	3	1
BLOOD_Leukemia	TSPY4 →	+1.014	+3.507	<.001	.004	3	1
BLOOD_Leukemia	ARL14EPL →	+0.085	+3.631	.001	.006	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

THEG by MIIP expression — BLOOD_Leukemia

Explore this box plot interactively →