MIGA2

Across TCGA patient cohorts, MIGA2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIGA2-associated genes across cancer lineages are eEF2, Notch1, and PKC-delta_pS664. Each is linked with MIGA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIGA2-to-partner and partner-to-MIGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MIGA2-low versus MIGA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIGA2→partner) and Y-score (partner→MIGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.441	+2.584	.002	.010	3	2
UCEC	Notch1 →	+0.171	+2.472	.002	.010	3	2
UCEC	PKC-delta_pS664 →	-0.100	-2.321	.037	.033	3	2
UCEC	PRDX1 →	+0.194	+2.999	.019	.035	3	2
UCEC	ATM →	-0.651	-2.415	<.001	.003	3	2
UCEC	A-Raf_pS299 →	-0.131	-1.906	.006	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by MIGA2 expression — UCEC

Explore this box plot interactively →